Peripartum cardiomyopathy linked to PTRH2 in Nature Communications study

Researchers at The Lundquist Institute report that the gene PTRH2 helps the maternal heart adapt to pregnancy, and that loss of PTRH2 in mouse models caused severe postpartum heart failure and persistent heart enlargement.

Scientists at The Lundquist Institute for Biomedical Innovation published a study in Nature Communications describing a molecular safeguard in the heart during pregnancy. The research focuses on the gene PTRH2 and its role in helping the maternal heart adapt to the stresses of pregnancy. Using advanced mouse models, the team examined what happens when PTRH2 is lost. Their reported results showed severe postpartum heart failure and a failure of the heart to return to its normal size after pregnancy when PTRH2 was absent. Key findings: - The study was published in Nature Communications and led by researchers at The Lundquist Institute. - The gene PTRH2 is reported to play a critical role in how the maternal heart adapts to pregnancy-related stress. - Experiments in advanced mouse models showed that loss of PTRH2 led to severe postpartum heart failure and persistent enlargement of the heart. - The paper names Michelle L. Matter, PhD, and co-first author Pooja Choubey, PhD, among the researchers involved. - The authors say the findings point to new therapeutic possibilities and emphasize the need for better treatments for peripartum cardiomyopathy. Summary: The findings shed light on a biological mechanism that may contribute to peripartum cardiomyopathy and provide a basis for further research into targeted approaches. Undetermined at this time.