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Alzheimer's reversed in mice after researchers restored brain NAD+
Summary
A study reports that restoring levels of the cellular molecule NAD+ in mice reversed advanced Alzheimer's and improved cognition; treated mice also showed normalized blood levels of phosphorylated tau 217.
Content
Scientists report a study in which advanced Alzheimer's was reversed in mice. The researchers found that human Alzheimer's brain samples showed a failure to maintain normal levels of the cellular energy molecule NAD+. In mouse models, restoring NAD+ in the brain was associated with reversal of disease features and recovery of cognitive function. The treated animals also had normalized blood levels of phosphorylated tau 217, a marker linked to Alzheimer's.
Key findings:
- Human Alzheimer's brain samples were reported to have reduced levels of the cellular molecule NAD+.
- In mouse models, restoring NAD+ in the brain was reported to reverse advanced Alzheimer's features and improve cognition.
- Treated mice showed normalized blood levels of phosphorylated tau 217.
- These results come from animal experiments and do not establish effects in people.
Summary:
The study reports that restoring NAD+ reversed advanced Alzheimer's features and cognition in mice and that human brain samples showed NAD+ deficiency. Undetermined at this time.
