Post‑mpox Africa CDC roadmap outlines plans for long-term health security.

Africa CDC has lifted mpox's designation as a Public Health Emergency of Continental Security and launched a Mpox Transition Roadmap to move from emergency response toward sustained control.

Africa CDC has lifted mpox's designation as a Public Health Emergency of Continental Security and is shifting from emergency operations to sustained, system-level control. The 2024–25 mpox surge highlighted gaps in surveillance, diagnostics and access to vaccines and therapeutics across the continent. In August 2024 Africa CDC declared mpox a PHECS to coordinate continental action and mobilise resources. The agency has now launched a Mpox Transition Roadmap to embed surveillance, laboratory, vaccination and research capacities into national health systems. Key facts: - In August 2024 Africa CDC declared mpox a Public Health Emergency of Continental Security to coordinate the continental response. - By the end of 2024 the continent reported 80,276 suspected mpox cases and 1,340 deaths, with the Democratic Republic of the Congo accounting for about 96% of reported cases and 97% of reported deaths. - More than US$1 billion in emergency financing was mobilised and genomic sequencing capacity was scaled up more than tenfold. - Vaccination campaigns delivered over five million mpox vaccine doses across 16 African countries, and a unified research agenda engaged more than 2,000 African and global scientists. - By late 2025 suspected cases fell by approximately 40%, confirmed cases by approximately 60%, and the suspected case fatality rate declined from 2.6% to 0.6%. Summary: The shift from a declared continental emergency toward a structured transition reflects measurable improvements in case numbers and fatalities and a move to embed response functions into routine systems. The Mpox Transition Roadmap is designed to preserve these gains by strengthening surveillance, laboratory networks, vaccination strategies, research and community-rooted risk communication, and by supporting local manufacturing and supply-chain resilience. Mpox remains endemic in some regions, so continued monitoring and integration into health systems are part of the roadmap's focus.