Broccoli and pomegranate could slow spread of prostate cancer

In a four-month trial of 212 men with low-risk prostate cancer, a supplement containing broccoli, pomegranate and other phytochemicals was linked to a slowing of PSA rise; adding a Lactobacillus probiotic was associated with a larger reduction in PSA progression and MRI-supported changes.

A clinical trial tested whether boosting phytochemical intake and gut bacteria could influence prostate cancer markers in men with low-risk disease. The study combined a supplement made from broccoli, pomegranate, turmeric, green tea, ginger and cranberry with either a specially designed Lactobacillus probiotic or a placebo. Researchers measured PSA in blood and used MRI scans over four months to assess disease activity. The authors described larger reductions in PSA progression and accompanying MRI changes among those who received the probiotic in addition to the supplement. Key findings: - 212 men with low-risk prostate cancer were enrolled in the four-month trial. - All participants took a phytochemical-rich supplement; half also received a Lactobacillus probiotic and half received a placebo. - PSA progression slowed across the study group, with a reported 44% greater reduction in PSA progression among those given the probiotic. - MRI results showed disease progression in 18% of the supplement-plus-placebo group versus 7.8% in the supplement-plus-probiotic group. - Several men in the supplement-plus-probiotic group showed disease regression on MRI, which was not observed in the other group. - Participants receiving both the supplement and probiotic reported improved urinary symptoms, fewer night-time visits to the bathroom and reduced erectile dysfunction; authors also reported reduced serum inflammation markers and increased strength. Summary: The trial reports short-term slowing of PSA rise and MRI-supported changes after use of a phytochemical supplement, with larger effects when combined with a Lactobacillus probiotic. The authors note the findings may be clinically relevant for men on active surveillance and plan longer follow-up; further research is needed and longer-term outcomes remain undetermined at this time.