Disrupted sleep is linked to 172 diseases in a large study

A June 2025 analysis of more than 88,000 UK Biobank participants found disrupted sleep patterns were associated with an increased risk across 172 diseases; researchers and clinicians noted the study is observational and does not prove causation.

Researchers reported in June 2025 that disrupted sleep patterns were associated with a higher risk across many diseases. The analysis used data from more than 88,000 people in the UK Biobank. Experts emphasized the study was observational and does not establish causation. The article summarizes common forms of sleep disruption, possible causes, and expert comments on treatment approaches. Key findings: - The study analyzed data from over 88,000 UK Biobank participants and identified associations between disrupted sleep and 172 diseases. - The linked conditions span multiple body systems, including metabolic, neurological, cardiovascular and respiratory disorders. - Examples mentioned in the report include Type 2 diabetes, Parkinson's disease, kidney and liver diseases, heart disease, stroke and respiratory conditions. - Reported forms of disrupted sleep include irregular bedtimes, low sleep–wake stability and sleep fragmentation; cited causes include circadian disruption, shift work, insomnia and sleep apnea. - Experts noted the research shows association rather than proven causation and described cognitive behavioral therapy for insomnia (CBT-I) as a well-supported treatment for chronic insomnia. Summary: The study found widespread associations between disrupted sleep patterns and many health conditions, reinforcing interest in sleep as a factor in long-term health. Undetermined at this time.