Paracetamol is safe in pregnancy, study finds

A large review published in The Lancet Obstetrics, Gynaecology & Women's Health analysed 43 high-quality studies and found no evidence that paracetamol taken during pregnancy raises the risk of autism, ADHD or intellectual disability, and the authors say prior links are likely due to other factors.

A major review published in The Lancet Obstetrics, Gynaecology & Women's Health reports no evidence that paracetamol taken during pregnancy increases the risk of autism, ADHD or intellectual disability in children. The researchers examined 43 high-quality studies, including sibling-comparison designs and long follow-up studies, covering hundreds of thousands of pregnancies. Study authors and external experts described the analysis as rigorous and said the findings should reassure pregnant women. The review responds to earlier public claims and to ongoing discussion among some US health officials about acetaminophen use in pregnancy. Key findings: - The review included 43 robust studies, many with sibling-comparison methods, and involved large participant numbers. - Researchers report no association between maternal paracetamol use and later diagnosis of autism, ADHD or intellectual disability. - Authors state that previously reported links are likely explained by other factors rather than a direct effect of paracetamol. - The review reinforces guidance from major medical organisations in the UK, US and Europe that paracetamol is a first-line option for pain and fever in pregnancy. - US health officials and some prior reviews have expressed concern about heavy or prolonged use of acetaminophen, but the FDA says a causal relationship with neurological conditions has not been established. Summary: The review is likely to reduce uncertainty among clinicians and pregnant people by reinforcing existing guidance that paracetamol remains a commonly recommended option for pain or fever in pregnancy. Undetermined at this time.